According to studies:
- ADE can make vaccinated people more susceptible to serious infection from the virus
- “ADE may be a concern” for those who have been vaccinated for Covid-19
- With ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in “increased viral replication and more severe disease, leading to major safety risks”
- ADE can also “occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don’t protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness”
- This concern was initially described by some scientists who were subsequently banned from media platforms that incorrectly claimed the scientists were disseminating disinformation
- Study scientists suggest the answer is to create a new vaccine
In a new study in the Journal of Infection, scientists explain one likely reason why so many vaccinated people are getting sick: a dangerous phenomenon called Antibody Dependent Enhancement or ADE.
Despite the fact that multiple medical authorities predicted, told us, and hoped, ADE would not impact Covid-19 vaccines, data from the study indicates it has done just that.
According to the new study, data suggests that the Covid-19 vaccines originally appeared to provide an overall benefit in fighting the virus. However, when it comes to one of the newer iterations of Covid, the Delta variant, the vaccines appear to facilitate infection displaying “a strikingly increased affinity” for the virus’ trademark spike protein.
The scientists conclude that “ADE may be a concern” for those who have been vaccinated for Covid-19.
According to scientific study, the ADE risk was well known prior to the Covid-19 vaccines being allowed on the market.
“One potential hurdle for antibody-based vaccines and therapeutics is the risk of exacerbating COVID-19 severity via antibody-dependent enhancement (ADE),” explained a study in Nature. “ADE can increase the severity of multiple viral infections, including other respiratory viruses such as respiratory syncytial virus (RSV) and measles.”
Scientists say that with ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in “increased viral replication and more severe disease, leading to major safety risks.”
“Non-neutralizing antibodies generated by past infection or vaccination fail to shut down the pathogen upon re-exposure. Instead, they act as a gateway by allowing the virus to gain entry and replicate in cells that are usually off limits… That, in turn, can lead to wider dissemination of illness, and over-reactive immune responses that cause more severe illness,” according to scientists.
An article in MedPage (prior to the new study) dismissed concerns about ADE, but noted it “can also occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don’t protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness.”
On the other hand, most scientific studies on this topic say those who have recovered from Covid-19 have natural immunity that does not display the same problem, and appears to be superior to that, so far, of that provided by the vaccines.
Nonetheless, the Centers for Disease Control (CDC) and many public health officials are pressing for more people to get vaccinated, including those who have been previously-infected with Covid. (Numerous studies suggest there is no benefit to recovered patients getting vaccinated.) The health officials state that the vaccinated patients who are getting Covid are getting milder forms than they would have if they had not been vaccinated. However, that is a case-by-case assumption and is impossible to prove.
In Israel, health officials say that only 1% among Covid infections in the latest wave are among those previously infected with Covid. The other 99% are among unvaccinated and not previously-infected, and among fully-vaccinated.
- The Clot Factor: A Full Measure Town Hall
- The Clot Factor
- The Microvascular Research Foundation
- Long Vax, Long Covid Resources
- Covid-19 Natural Immunity: The Definitive Summary
- Covid-19 Vaccine: 80 of the Most Common Adverse Events
- Covid-19 Vaccine Concerns Summary
- Covid-19 Vaccine Analysis: Common Adverse Events
- Covid-19 Origins: Separating Rumor from Fact (WATCH)
- Report a Possible Vaccine Adverse Event
According to the new study, the solution to the current ADE problem is to invent a new, updated version of the vaccine.
Children’s Hospital of Philadelphia (which accepts funding from the vaccine industry) reports the following about ADE:
A major goal of antibodies is to bind to the pathogen and prevent it from infecting, or entering, a cell. Antibodies that prevent entry into cells are called neutralizing antibodies. Many vaccines work by inducing neutralizing antibodies. However, not all antibody responses are created equal. Sometimes antibodies do not prevent cell entry and, on rare occasions, they may actually increase the ability of a virus to enter cells and cause a worsening of disease through a mechanism called antibody-dependent enhancement (ADE).
What is ADE?
ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.
Is ADE caused by vaccines?
On a few occasions ADE has resulted from vaccination:
- Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from pneumonia after infection with RSV. As a result of this finding, the vaccine trials stopped, and the vaccine was never submitted for approval or released to the public.
- Measles — An early version of measles vaccine was made by inactivating measles virus using formaldehyde. Children who were vaccinated and later became infected with measles in the community developed high fevers, unusual rash, and an atypical form of pneumonia. Upon seeing these results, the vaccine was withdrawn from use, and those who received this version of the vaccine were recommended to be vaccinated again using the live, weakened measles vaccine, which does not cause ADE and is still in use today.
A more recent example of ADE following vaccination comes from dengue virus:
- Dengue virus — In 2016, a dengue virus vaccine was designed to protect against all four serotypes of the virus. The hope was that by inducing immune responses to all four serotypes at once, the vaccine could circumvent the issues related to ADE following disease with dengue virus. The vaccine was given to 800,000 children in the Philippines. Fourteen vaccinated children died after encountering dengue virus in the community. It is hypothesized that the children developed antibody responses that were not capable of neutralizing the natural virus circulating in the community. As such, the vaccine was recommended only for children greater than 9 years of age who had already been exposed to the virus.
Should I be concerned that my child will develop ADE after receiving a vaccination?
Today’s routinely recommended vaccines do not cause ADE. If they did, like those described above, they would be removed from use. Phase III clinical trials are designed to uncover frequent or severe side effects before a vaccine is approved for use.
Read more from the new study below:
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.The aim of the present study was to evaluate the recognition of SARS-CoV-2 Delta variants by infection enhancing antibodies directed against the NTD. The antibody studied is 1054 (pdb file #7LAB) which has been isolated from a symptomatic Covid-19 patient1. Molecular modelling simulations were performed as previously described2. Two currently circulating Delta variants were investigated, with the following mutational patterns in the NTD :
- – G142D/E154K (B.1.617.1)
- – T19R/E156G/del157/del158/A222V (B.1.617.2)
Each mutational pattern was introduced in the original Wuhan/D614G strain, submitted to energy minimization, and then tested for antibody binding. The energy of interaction (ΔG) of the reference pdb file #7LAB (Wuhan/D614G strain) in the NTD region was estimated to -229 kJ/mol−1. In the case of Delta variants, the energy of interaction was raised to -272 kJ.mol−1(B.1.617.1) and -246 kJ.mol−1 (B.1.617.2). Thus, these infection enhancing antibodies not only still recognize Delta variants but even display a higher affinity for those variants than for the original SARS-CoV-2 strain.The global structure of the trimeric spike of the B.1.617.1 variant in the cell-facing view is shown in Figure 1A. As expected, the facilitating antibody bound to the NTD (in green) is located behind the contact surface so that it does not interfere with virus-cell attachment. Indeed, a preformed antibody-NTD complex could perfectly bind to the host cell membrane. The interaction between the NTD and a lipid raft is shown in Figure 1B, and a whole raft-spike-antibody complex in Figure 1C. Interestingly, a small part of the antibody was found to interact with the lipid raft, as further illustrated in Figures 1D-E. More precisely, two distinct loops of the heavy chain of the antibody encompassing amino acid residues 28-31 and 72-74, stabilize the complex through a direct interaction with the edge of lipid raft (Figure 1F). Overall, the energy of interaction of the NTD-raft complex was raised from -399 kJ.mol−1 in absence of the antibody to -457 kJ.mol−1 with the antibody. By clamping the NTD and the lipid raft, the antibody reinforces the attachment of the spike protein to the cell surface and thus facilitates the conformational change of the RBD which is the next step of the virus infection process2.
Y’all need to do your own research. Read the science yourself. Question everything from all sides. But get the truth from the actual scientists. A little knowledge can be dangerous. There is plenty of real scientific data out there indicating that the vaccine does not cause ADE.
Does anyone have an opinion regarding Novavax’s new Covid-19 Vaccine (nvx-cov-2373)? It’s not based on any of the technologies utilized so far.
IMO (I’m not a doctor), we are not seeing ADE, yet. In Israel, even though the vaccine doesn’t appear to limit infection or stop spread, it does appear to reduce the severity of illness. If ADE were occurring, one would think that increased viral loads would lead to increased severity of illness.
Not only is Sharyl ethical and brilliant, she’s pretty darn good looking too.
https://www.medpagetoday.com/special-reports/exclusives/94190
ADE has been looked in and is disputed since this is a theory and did not show up in animal studies. Furthermore the people getting sick post vaccine would be seeing worse symptoms. Just looking for the whole picture. Not debating it’s a concern and has been from the start.
From what I’ve read, no one can be sure how long it will take for ADE to exhibit itself. Maybe there was a reason vaccines took typically 10 years to develop?
1. Only Pfizer vaccine has been fully approved by FDA.
2. Commissioner of FDA retired and was placed on Pfizer board of directors.
Question: What is relation of 1 and 2? Causal? Coincidence?
-Suggestion for Dr Fauci and health bureaucracy: To inspire confidence, repeated self-contradictions are not optimal. (Candidate for understatement of the year.)
-Suggestion for everyone: Statutory and case law REQUIRES informed consent for any medical procedure more complex than drawing a blood specimen. Where are consent forms for vaccines, listing potential benefits and side-effects? Why are attempts to describe side-effects censored by media? This is opposite of informed consent. It is enforced compliance. Again, not optimal for inspiring confidence.
Where I work, we were all exposed to someone who had a family member with COVID. Of the 6 people exposed, 5 got COVID and they were all vaccinated. I did not get it, despite being unvaccinated. I did have something with all the symptoms of COVID in 2019 (lack of smell, taste, concrete in the lungs, extreme fatigue). I believe that I have natural immunity (although I am not planning to test that if I can avoid it) I am not going to get vaccinated because I have already had anaphlaxis a couple of times and have no desire to experience that again. I DO NOT FEEL THAT WE ARE BEING GIVEN SUFFICIENT DATA ABOUT A NEW TECHNOLOGY TO MAKE INFORMED MEDICAL DECISIONS. I also do not feel that the vaccine is a silver bullet.
Fortunately there’s no evidence that ADE is occurring for Covid-19. It’s just a theoretical possibility, as it has occurred in the past for some vaccines. All the actual clinical and epidemiological evidence actually shows that fully vaccinated people are less likely to get Covid-19, and get less sick when they do, even for the delta variant. ADE was actually a concern when designing the Covid-19 vaccines, and they looked for signs of it in the clinical trials and didn’t see it. So you’re all good, people, don’t worry about it.
The paper cited is just a mathematical modelling study, and contains no clinical data or even in vitro experiments. As a scientist I’ve seen a lot of studies like this, and it’s just speculative. People are always publishing mathematical modelling studies that show this or this could happen, but more often than not, when the experiments are done, it doesn’t occur, because the real world is much more complex than a simplified model.
I’m only a nurse with a minor in microbiology but the first problem is defining wtf a vaccine is and isn’t.
Vaccine
A preparation of a weakened or killed pathogen, such as a bacterium or virus, or of a portion of the pathogen’s structure that upon administration to an individual stimulates antibody production or cellular immunity against the pathogen but is incapable of causing severe infection.
Gene Therapy
Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material
Messenger RNA
In molecular biology, messenger ribonucleic acid is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein.
Pfizer and Moderna are not vaccines. It’s genetic engineering. And the mrna technology has never reached 77% success in human trials.
I won’t get it. I’m not antivaxx necessarily. I have been personally impacted. Step father is severely disabled from childhood polio. Vaccines made crippled dead 7 years old kids a bad memory because we eradicated polio. But not all viruses are the same or even well understood science. But regardless of opinions on vaccines in particular we are discussing genetic coding. We’re discussing possible horrors. And it wouldn’t be the first time vaccines were used in genocide. The WHO caused 100 million women sterility and spontaneous abortions in Africa. It’s well documented. And the US has been involved in ethnic cleansing and genocide from day one. Eugenics carried out on Indian reservations on women via Indian health services until 1976. I’m a citizen of Choctaw nation of Oklahoma. And like many poc communities I have legitimate reason to not only hate this government but regard it as a malignancy. Eugenics carried out through Indian health services only stopped a year before my own birth. 1976. I’m also a vet. I didn’t enlist because of warped patriotism ideas but because despite myth we don’t get free college. And everything I’ve observed in my childhood as an army brat, my service, and work in the medical field as a nurse 20 years is telling me something is very wrong. From the pandemic, the virus, the numbers given to the public and the treatment /vaccines.
If forced I will get the Johnson and Johnson vaccine. A true vaccine and science with decades of information about it’s mechanism and risks. I will not get the mrna. And the coercion tactics to force the vaccine is a violation of bodily autonomy. Bodily autonomy is not a convenient argument for only abortion. And using public health as a reason to violate bodily autonomy is still stripping basic human rights. Nothing new here tho or we wouldn’t have prisons full of drug users.
So the bottom line is that the NIH, CDC and FDA are not consumer protection agencies. Rather, they serve the business interests of those companies they pose to regulate?
Yes, when six members of CDC now ‘entitled’ to personal vaccines royalties of $150K PER YR THE REST OF THEIR LIVES in what world does that make someone a civil servant? Sure explains a lot beyond Herr Fauzi as well (source:Kennedy, Frontline Doctors, via Vaccine Secrets episode 1)
this Fall vaxxed people will start dropping like flies, Big Pharma will start flogging several new and improved meds at exorbitant prices and the pols will demand double masks and semi permanent lockdowns.
I for one am sick and tired of this scamdemic and the tyrants running it.
If I got the one dose but do not want to get the second dose am I better off?
Thymosin alpha 1 apears to be helpful. I am 67 male and use Ancestrial Supplements grass fed Thumus, it has has positive affects on me in a short time. I have read about the thumus and its importance. Love your work.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747025/
Facebook is now stepping on this article with false, twisted “fact-checking.” They use an old, outdated article to state that ADE didn’t show up in early clinical trials, therefore it “doesn’t exist. ( https://healthfeedback.org/claimreview/no-evidence-that-covid-19-vaccines-cause-more-severe-disease-antibody-dependent-enhancement-has-not-been-observed-in-clinical-trials/?fbclid=IwAR0LTRL_ufI6cGS9zQXfy7BpMq0pzINkTxQ3WFEETUryzD0Od6qN7U2_4QI 0
Except now, MILLIONS of doses of vaccine have now been administered. This makes their “fact check” malarkey. Their disinformation campaign continues to malign and discredit honest reporting (thank you, Ms. Atkisson) and honest medical researchers, and do untold harm to the public!!
Facebook claims there is “Partly False Information” in this article
Ur right but if u ever caught covid or any child had it bad enough to go to the hospital wouldnt u be the first.person to trust whatever they had to do to save ur kid? Heard.if it many times anti vacinne people get sick and say do whatever u have to to save them??
Not being anti-vaccine, and having a fully vaccinated child, I’m not sure what I would do if my child got very sick with an illness. I definitely would not “trust whatever they had to do” because Im familiar with too many missteps made by medical professionals, though there are many wonderful competent doctors. I do have a trusted circle of medical professionals I would consult and probably consider their advice above others.
Yes. I agree. I think of doctors as pizza makers. There are a lot of choices, they all use the same ingredients yet only a few make good pizza. You know good pizza when you have tried it. I find the best doctors listen intently to their patients for clues. If your Dr is rushed with you or is t paying attention when you speak, find another Dr. His mind is made up before you finished describing symptoms. They think they’ve seen it a thousand times. The best doctors wait until all info is known and then and only then, are they confident is verifying their thoughts with testing. Good luck to everyone. I think this is a biological weapon unleashed on us by communists who history has shown cares little for human life or suffering.
Cold Spring Harbor Labs ref. biologist peers – read the comments. (blue icon)
https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1.abstract
note the attributions to the submitted paper incl. BioNTech gmBH CEO and CMO.
This “FDA approval” is monumentally unscientific at best and corrupt at worst.
I do not believe the study referenced made any delineation between whether the antibodies were developed via natural infection or vaccination. If ADE is a possibility for either case, then in fairness , that weakens this argument somewhat. On the flip-side, if someone can demonstrate via research/studies that ADE manifests more frequently/strongly in vaccinated individuals, that strengthens the case. Does anyone have any data to this point?
One of the worst things we (who oppose this vaccine) can do at a time like this is misconstrue data from a study – we know the opposing side does this all the time & are not held to account, but they will call us on it any day.
This was my thought too. There truly is misinformation and deception on both sides of the argument. The problem is that this whole thing was so politicized (because everything is politicized these days) that we got constantly shifting and unreliable information from people claiming to be experts. There’s almost nobody you can trust. Let’s be cautious in our acceptance of any information.
What relation to this does the “cytokine storm” have?
right on
I keep reading these articles about unvaccinated people dying within a month of getting COVID. And then I see articles like this. What are the real numbers for vaccinated vs. unvaccinated?
Exactly! You are considered unvaccinated until 2 weeks AFTER the second shot. So that is a 42 day window where you are partially vaccinated but yet reported as unvaccinated. I want to know the real numbers of partially vaccinated in hospital vs fully unvaccinated.
Off topic. I’m amazed at the two systems of health we have now going completely unreported, by anyone.
If you are a famous politician or person, and get tested positive, you receive this antibody treatment like Texas Gov. Abbott or Pres. Trump (and I’m sure anyone with connections) and if you’re just a chump citizen you get sent home to die. Two people I know became tremendously sick 105 plus temp and didn’t receive any treatment. One has damaged heart, one bad lungs.
Too bad for you.
The hospitals would not admit them. I’m just sick over this.