The following is from an article published in MDPI – Publisher of Peer Reviewed Open Access Journals.

A new study illustrates that the onset of debilitating symptoms following SARS-CoV-2 vaccination is thought to constitute a new, novel disease entity, for which the term post-acute Covid-19 vaccination syndrome (PACVS) has been suggested.

The symptoms reported by PACVS-affected persons start shortly after SARS-CoV-2 vaccination, continue in episodes over several months, and severely compromise the quality of life.

A systematic survey of the clinical features of PACVS has yet to be carried out.

However, published case reports indicate that PACVS differs from the usual adverse effects of SARS-CoV-2 vaccination.

The symptoms most frequently reported in the context of PACVS encompass impaired well-being (exhaustion, malaise, chronic fatigue), cardiovascular disturbances (orthostatic intolerance, tachycardia, palpitations), peripheral neuropathy (dysesthesia, hypesthesia), central nervous system dysfunction (lack of concentration, brain fog, cognitive deficits, sleep disorders), muscular dysfunction (myalgia, weakness, fibrillations), and gastro-intestinal afflictions (nausea, strong weight changes).

In summary, PACVS presents a phenotype of acquired autonomous dysfunction that overlaps with various established multisystemic dysautonomia syndromes such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), fibromyalgia/chronic pain syndrome, small fiber neuropathy (SFN) and mast cell activation syndrome (MCAS).

Interestingly, symptoms similarly conforming to ME/CFS and POTS have been observed following vaccinations against human papillomavirus and hepatitis B virus.

Dysautonomia syndromes unrelated to vaccination are frequently associated with alterations of humoral autoimmunity against receptors and transmitters involved in autonomous regulation. Increases in circulating levels of these antibodies are linked to the incidence, duration and severity of ME/CFS and POTS.

IgG-directed therapy has been successful in ameliorating symptoms. Increases in circulating receptor antibodies were also observed in severe Covid-19, which similarly exhibits ME/CFS-like symptoms amenable to IgG-directed therapy.

Taken together, the above considerations prompt the hypothesis that antibodies against autonomous regulation elements could play a role in PACVS and possibly serve as therapeutic targets or diagnostic markers.

To address this hypothesis, we have here investigated the impact of SARS-CoV-2 vaccination on receptor antibodies known to be involved in POTS, ME/CFS and immune homeostasis.

Circulating levels of these antibodies were measured before and six months after vaccination in normal healthy individuals not affected by PACVS.

Normal post-vaccination levels were compared with corresponding levels of a matched cohort presumed to be affected by PACVS because exhibiting persistent symptoms of chronic severe autonomous dysfunction following SARS-CoV-2 vaccination.

Read full abstract and study here.

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